Using Fluorescence to Enable Innovative Functions of Foldamers

Document Type

Article

Publication Date

3-2021

Publisher

John Wiley & Sons, Inc

Abstract

Monodisperse, sequence-specific oligomers that adopt regular three-dimensional structures, termed foldamers, have found widespread use as biomimetics, sensors, and novel materials. This review highlights recent examples in which steady state and time-resolved fluorescence techniques have clarified foldamer structure or enabled the development of foldamers with exciting and sophisticated functions. Applications of foldamers include their development into bioactive compounds, supramolecular hosts or sensors, and materials with useful optical properties. Examples that illustrate the use of natively fluorescent and fluorophore-modified foldamers are discussed along with studies of fluorophore interactions with varied dyes.

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