Date of Award


Document Type



Santa Clara : Santa Clara University, 2022.



First Advisor

Zhiwen (Jonathan) Zhang


According to the World Health Organization, antibiotic resistance is one of the biggest threats to global health, food security, and development today. A growing number of infections, like Methicillin-resistant Staphylococcus aureus, are becoming harder to treat as the antibiotics used to treat them become less effective. As a result, the primary concern for infections in the hospital setting is due to the S. aureus’s growing resistance to antibiotics. Therefore, in response to this global health threat, our project focuses on furthering the research in developing a drug that S. aureus will not develop resistance to. In this paper, we assess NPY-Y2 as a potential immuno-anti-infective drug target to prevent the activation of Sortase A on S. aureus. We have shown that NPY-Y2 is a potential drug target; however, further invasion assay experiments need to be conducted for more reliable verification. In a larger scheme, our hope is that the approach of this research will allow for the development of other anti-infective drugs for other bacteria.