Date of Award
6-2022
Document Type
Thesis
Publisher
Santa Clara : Santa Clara University, 2022.
Department
Bioengineering
First Advisor
Maryam Mobed-Miremadi
Abstract
Scale the reported hydrodynamic shear values in industrial bioreactors for monoclonal antibody production to the shear stress measured in our custom microneedle prototype by extruding microencapsulated CHO cells. A correlation between the number of extrusion loops to reduction in cell viability enables a scalable screening method for bioprocessing efficiency.
Recommended Citation
Defelippi, Kendall and Johnson, Dwight, "Shear Detection of Microencapsulated Cells for Monoclonal Antibody Production Scaleup" (2022). Bioengineering Senior Theses. 120.
https://scholarcommons.scu.edu/bioe_senior/120
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