Date of Award

6-2022

Document Type

Thesis

Publisher

Santa Clara : Santa Clara University, 2022.

Department

Bioengineering

First Advisor

Prashanth Asuri

Abstract

In this project, we investigate how innate hydrogel properties can be leveraged for controlled protein drug release platforms. Therapeutic proteins have many valuable applications within the medical field, however, professionals often face many obstacles with obtaining controlled drug release. This paper analyzes how the manipulation of hydrogel properties can improve protein drug release rates. We started these investigations by varying hydrogel concentrations since we saw that this affects the release of small molecules. Additionally, we wanted to see what the addition of a second hydrogel network would do to protein release rates. These experiments concluded that raising polymer concentrations and adding secondary polymers to hydrogel drug delivery systems resulted in more linear and controlled protein release profiles.

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