In situ formation and reaction of 2-pyridylboronic esters
Document Type
Article
Publication Date
3-2003
Publisher
Elsevier
Abstract
2-Pyridylboronic esters were generated by cross-coupling 2-bromopyridines with bis(pinacolato)diboron in the presence of a base and palladium catalyst. The boronic esters reacted in situ with unreacted 2-bromopyridines to afford high yields of 2,2′-bipyridines as homocoupled products. Depending upon the reaction conditions, varying amounts of protodeboronated products were also observed. An attempted cross-coupling between two different 2-bromopyridines produced a nearly statistical mixture of homo- and cross-coupled products.
Recommended Citation
Fuller, A. A., Hester, H. R., Salo, E. V., & Stevens, E. P. (2003). In situ formation and reaction of 2-pyridylboronic esters. Tetrahedron Letters, 44(14), 2935–2938. https://doi.org/10.1016/S0040-4039(03)00419-2
