Synthesis and Structural Characteristics of Geminally Disubstituted β-Amino Acids

Authors

• Amelia A. Fuller, Santa Clara UniversityFollow
• Bin Chen
• Aaron R. Minter
• Anna K. Mapp

Document Type

Article

Publication Date

7-2004

Publisher

Georg Thieme Verlag Stuttgart

Abstract

The syntheses of seven new β-amino acids containing aryl, alkyl, and heteroaryl substituents are outlined. The synthetic strategy employs densely functionalized chiral isoxazolines as key intermediates, enabling the preparation of single stereoisomers of these challenging targets. Solid-state characterization of two of the sterically encumbered targets is also reported.

Recommended Citation

Fuller, A. A., Chen, B., Minter, A. R., & Mapp, A. K. (2004). Synthesis and Structural Characteristics of Geminally Disubstituted β-Amino Acids. Synlett, 2004(08), 1409–1413. https://doi.org/10.1055/s-2004-829051