Document Type
Article
Publication Date
1-11-2019
Publisher
John Wiley & Sons, Inc
Abstract
Peptoids are versatile peptidomimetic molecules with wide-ranging applications from drug discovery to materials science. An understanding of peptoid sequence features that contribute to both their three-dimensional structures and their interactions with lipids will expand functions of peptoids in varied fields. Furthermore, these topics capture the enthusiasm of undergraduate students who prepare and study diverse peptoids in laboratory coursework and/or in faculty led research. Here, we present the synthesis and study of 21 peptoids with varied functionality, including 19 tripeptoids and 2 longer oligomers. We observed differences in fluorescence spectral features for 10 of the tripeptoids that correlated with peptoid flexibility and relative positioning of chromophores. Interactions of representative peptoids with sonicated glycerophospholipid vesicles were also evaluated using fluorescence spectroscopy. We observed evidence of conformational changes effected by lipids for select peptoids. We also summarize our experiences engaging students in peptoid-based projects to advance both research and undergraduate educational objectives in parallel.
Recommended Citation
Jimenez, C. J., Tan, J., Dowell, K. M., Gadbois, G. E., Read, C. A., Burgess, N., Cervantes, J. E., Chan, S., Jandaur, A., Karanik, T., Lee, J. J., Ley, M. C., McGeehan, M., McMonigal, A., Palazzo, K. L., Parker, S. A., Payman, A., Soria, M., Verheyden, L., … Stokes, G. Y. (2019). Peptoids advance multidisciplinary research and undergraduate education in parallel: Sequence effects on conformation and lipid interactions. Biopolymers, 110(4), e23256. https://doi.org/10.1002/bip.23256
Comments
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.