Document Type
Article
Publication Date
11-26-2020
Publisher
American Chemical Society
Abstract
New antibiotics are urgently needed to address increasing rates of multidrug resistant infections. Seventy-six diversely functionalized compounds, comprising five structural scaffolds, were synthesized and tested for their ability to inhibit microbial growth. Twenty-six compounds showed activity in the primary phenotypic screen at the Community for Open Antimicrobial Drug Discovery (CO-ADD). Follow-up testing of active molecules confirmed that two unnatural dipeptides inhibit the growth of Cryptococcus neoformans with a minimum inhibitory concentration (MIC) ≤ 8 μg/mL. Syntheses were carried out by undergraduate students at five schools implementing Distributed Drug Discovery (D3) programs. This report showcases that a collaborative research and educational process is a powerful approach to discover new molecules inhibiting microbial growth. Educational gains for students engaged in this project are highlighted in parallel to the research advances. Aspects of D3 that contribute to its success, including an emphasis on reproducibility of procedures, are discussed to underscore the power of this approach to solve important research problems and to inform other coupled chemical biology research and teaching endeavors.
Recommended Citation
Fuller, A. A., Dounay, A. B., Schirch, D., Rivera, D. G., Hansford, K. A., Elliott, A. G., Zuegg, J., Cooper, M. A., Blaskovich, M. A. T., Hitchens, J. R., Burris-Hiday, S., Tenorio, K., Mendez, Y., Samaritoni, J. G., O’Donnell, M. J., & Scott, W. L. (2020). Multi-Institution Research and Education Collaboration Identifies New Antimicrobial Compounds. ACS Chemical Biology, 15(12), 3187–3196. https://doi.org/10.1021/acschembio.0c00732
Comments
This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.