Date of Award

Spring 2020

Document Type

Thesis

Publisher

Santa Clara : Santa Clara University, 2020.

Department

Bioengineering

First Advisor

Emre Araci

Abstract

Leukemia is a deadly and common cancer, especially in children and adolescents. The misdiagnosis and unexpected complications during the treatment are some factors that increase the mortality rate of leukemia. The goal of our project was to create a device that would quickly and accurately assess these complications. While there are existing tests that can perform a single test for either metastasis or sepsis, there are none that can test for both simultaneously and rapidly. We propose to modify and combine some of these existing microfluidic designs as well as create a new component to perform a combinatorial assessment. While we were unable to verify the results, we have designed a device that will potentially meet our goals of testing for sepsis, severe sepsis, solid-body metastasis risk, major solid-body metastasis risk, lymphoma metastasis risk, and progression of the primary blood-based cancer (leukemia/lymphoma), from 7.5 mL of blood in just under 2 hours. We believe that this device has the potential to contribute to the medical field due to its speed and efficiency, especially in a pediatric demographic.

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