Date of Award

6-2018

Document Type

Thesis - SCU Access Only

Publisher

Santa Clara : Santa Clara University, 2018.

Department

Bioengineering

First Advisor

Maryam Mobed-Miremadi

Abstract

Cell-based therapy is an emerging technology that offers the potential to treat a wide variety of wounds and cure diseases. Specifically, cell therapy is a promising option for dermatological treatment, including the healing of skin wounds, burns, scars, and pigmentation disorders. Transdermal cell delivery, or delivery of cells into the skin through the stratum corneum skin layer, is an emerging technique for cell-based dermatological treatment, and is still a novel concept to this day.

The goal of our project is to design and develop a minimally invasive 3D printable device that allows for transdermal delivery of encapsulated cells via hollow microneedle structures. Our group was successful in demonstrating the feasibility of biopolymer-encapsulated cells and the achievement of cell protection from shear degradation following extrusion through our device’s microneedle structures, providing a foundation for applications of transdermal wound healing therapies centering on hydrogel-encapsulated cell delivery.

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