Date of Award

6-15-2017

Document Type

Thesis - SCU Access Only

Publisher

Santa Clara : Santa Clara University, 2017.

Department

Bioengineering

First Advisor

Maryam Mobed-Miremadi

Second Advisor

Zhang, Zhiwen

Abstract

The Biologic Therapeutic Patch is a trilayer biocompatible patch that delivers an antioxidant therapeutic. The purpose of this product is to facilitate the initial stages of wound healing and enhance the healing process as a whole. Alginate patches were reproducibly fabricated and proven to be robust to degradation up to 4-5 hours in physiologically simulated fluid (PBS at 37 ° C). In addition to this, it was proved that Superoxide Dismutase increases cell proliferation at 10^4 cells/ml (0.01-0.05 U/ml) after hypoxic induction via the cytotoxic agent Cobalt Chloride (25 mM). Preliminary results indicate that the alginate patch is not cytotoxic to cells and is a candidate reservoir for the therapeutic agent Superoxide Dismutase. The preclinical models developed were successful in obtaining data that support the overall validity of the therapeutic patch design.

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