Date of Award
Santa Clara : Santa Clara University, 2022.
Scale the reported hydrodynamic shear values in industrial bioreactors for monoclonal antibody production to the shear stress measured in our custom microneedle prototype by extruding microencapsulated CHO cells. A correlation between the number of extrusion loops to reduction in cell viability enables a scalable screening method for bioprocessing efficiency.
Defelippi, Kendall and Johnson, Dwight, "Shear Detection of Microencapsulated Cells for Monoclonal Antibody Production Scaleup" (2022). Bioengineering Senior Theses. 120.