Date of Award

6-2021

Document Type

Thesis - SCU Access Only

Publisher

Santa Clara : Santa Clara University, 2021.

Department

Bioengineering

First Advisor

Zhiwen Zhang

Abstract

Infectious diseases are common causes of morbidity worldwide, and antibiotics are always the first-line treatment for combating the infections. Despite the significant function of antibiotics, the emergence of antibiotic-resistant bacterial strains has rendered them ineffective in many cases. The incentive of the medical field to strive to discover an alternative treatment for bacterial infection is immense. In particular, Methicillin-resistant staphylococcus aureus infection, a type of Gram-positive bacterial infection that resists multiple drugs, has posited one of the greatest health threads, resettling in thousands of deaths annually in the U.S. By understanding modes of the mechanism responsible for the pathogenicity of the bacterial strain, novel therapeutic approaches, such as immunotherapy, can be effectively designed to fight against the infection without further advancing the antibiotic-resistance crisis that threatens the humanity.

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