Engineering a Synthetic AntiEngineering a Synthetic Antibody for Pancreatic Cancer Detectionbody for Pancreatic Cancer Detection
Date of Award
Thesis - SCU Access Only
Santa Clara : Santa Clara University, 2019
Pancreatic cancer is expected to be the second leading cause of cancer-related deaths by 2030, mainly because early detection is so difficult. The most common biomarker, CA 19-9, for pancreatic cancer has a low success rate for early detection. We aim to incorporate the unnatural amino acid L-DOPA in a peptide to increase the binding affinity between the protein and CA 19-9. Our results will show that a protein-sugar interaction can occur, which would expand the capabilities for other disease diagnostics.
Beary, Madison; Carter, Kyle; and Girma, Nathaniel, "Engineering a Synthetic AntiEngineering a Synthetic Antibody for Pancreatic Cancer Detectionbody for Pancreatic Cancer Detection" (2019). Bioengineering Senior Theses. 85.
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