Date of Award

6-8-2016

Document Type

Thesis - SCU Access Only

Publisher

Santa Clara : Santa Clara University, 2016.

Department

Bioengineering

First Advisor

Zhiwen Zhang

Abstract

This project evaluates tumor volume in Balb/C mice inoculated with CT-26 tumor cells to understand the efficacy of small molecule and immunotherapy drugs used individually in comparison to combination therapy solutions. We hope that using the small molecule drugs in conjunction with an antibody will enhance the effects that the small molecule drug would have on its own. We believe that the additional targeting power of the monoclonal antibody will increase the potency of the small molecule drug in tumor suppression while limiting systemic side effects. This study will determine the efficacy of the small molecule drug and antibody drug independently and also evaluate how this data is affected by using these two drugs in combination.

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